![]() In one study using quadripulse TMS, a subset of subjects (with unknown caffeine habits) experienced robust potentiation in response to stimulation with placebo but had blunted responses with 200 mg of caffeine plus quadripulse stimulation ( 10). Notwithstanding the beneficial effects of caffeine for memory rescue ( 9) and LTP ( 1), two human studies suggest that acute caffeine intake may diminish or reverse the LTP-like after-effects of brain stimulation protocols (quantified from pre-post changes in peak-to-peak MEP amplitude). In this context, TMS can probe the role of caffeine on human brain plasticity. MEPs can detect changes in excitability when collected before and after stimulation, and are widely considered to reflect underlying plasticity, such as LTP ( 7, 8). TMS can also be paired with electromyography (EMG) recordings to measure corticomotor excitability via motor evoked potentials (MEPs). Repetitive transcranial magnetic stimulation (rTMS) is a treatment tool for neuropsychiatric disorders theorized to work through LTP, as demonstrated by animal and human work ( 2– 6). A1 receptor antagonism has been demonstrated to strengthen synapses through long-term potentiation (LTP), while A2A antagonism attenuates LTP ( 1). Caffeine is a ubiquitous psychostimulant which functions as a competitive, non-selective adenosine receptor antagonist of A1 and A2A subtypes.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |